Major topics:

1. Mechanisms associated with the dynamics of heat acclimation based on the marriage between integrative physiology and the transcriptome/proteome.

2. Heat acclimation mediated cytoprotective

memory-Origins in within-life epigenetics?

3. Heat acclimation mediated cross tolerance

to novel stressors

4. Exertional heat stroke-induction of heat intolerance. Is it epigenetics.

 For  experimental models# 1-3: -the heart  and the brain are our guides

Experimental goal #4 involves physiology-genomic linkage in humans.