Dr. Yona Simon (PhD)
Mononuclear phagocytes are a group of white blood cells that play an important role in the body's immune response. The Mononuclear Phagocyte System consists of three types of cell: monocytes, macrophages and dendritic cells (DC), each with distinct functions. Previously, it was believed that tissue macrophages were derived from blood monocytes, made in our bone marrow. However, more recently studies including our own, have revealed that macrophages originate before birth, while monocytes are continuously produced in the adult. Currently, we have an incomplete understanding of how these cells operate in humans. In the lab we study human monocyte, DC and macrophage dynamics and function under steady state and during disease to gain insights into how these cells are regulated and regulate physiological and pathological processes. This will potentially enable the development of new treatments, based on a better understanding of how the body responds to inflammation.
E-mail: s.yona@mail.
huji.ac.il
WebSite : https://yonalab.huji.ac.il/