Oral and Maxillofacial Surgery

The physicians of the department of oral and maxillofacial surgeries practice basic and clinical research studies, in addition to the daily medical care.

Basic science research applies classic experiments of various biomaterials, cells, tissues and models, while clinical research practices analysis of past, present and future medical cases and procedures.

We believe that research pushes our field forward for the development of faster, more efficient and minimally invasive therapies


Ongoing studies include:

  • The use of immune system cells to control the spread of malignant cancerous tumors. This pre-clinical study is performed in collaboration of our colleagues from the Providence Cancer Institute, Portland, Oregon, USA. In this study we seek new channels in which the patient’s own immune system can be activated to fight-back malignant tumors
  • Characterization of the immune system’s role within pre-malignant lesion of the oral cavity. We are looking for the “finger-print” of immune system components within samples biopsied from these lesions and investigate the correlation to the progression toward malignant tumors
  • Conservative surgical treatment for patients diagnosed with Odontogenic ameloblastoma. In this study we provide alternative to patients with this benign, yet aggressive tumor, through routine frequent follow-up evaluations, instead of vast ablation and resection. Our aim is to explore the benefits of this treatment modality and to correlate with chances of recurrence
  • The use of the Amelogenin protein for the treatment of sensory nerve injury. This is a basic science pre-clinical study in which we research the potential of a genetically engineered recombinant protein for the repair on the injured nerve
  • Minimally invasive endoscopy of salivary glands
  • The use of laser-assisted lithotripsy for the treatment of sialoliths (salivary glands stones)


List of publications

year 2018

Nupharidine Enhances Aggregatibacter actinomycetemcomitans Clearance by Priming Neutrophils and Augmenting Their Effector Functions.

  • Levy DH, Chapple ILC, Shapira L, Golan-Goldhirsh A, Gopas J, Polak D.
  • J Clin Periodontol. 2018 Oct 29. doi: 10.1111/jcpe.13036. [Epub ahead of print]


Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.

  • Heyman O, Koren N, Mizraji G, Capucha T, Wald S, Nassar M, Tabib Y, Shapira L, Hovav AH, Wilensky A.
  • Front Immunol. 2018 Aug 15;9:1712. doi: 10.3389/fimmu.2018.01712. eCollection 2018.


Bone Regeneration With Bovine Bone Impairs Orthodontic Tooth Movement Despite Proper Osseous Wound Healing in a Novel Mouse Model.

  • Klein Y, Fleissig O, Stabholz A, Chaushu S, Polak D.
  • J Periodontol. 2018 Jul 30. doi: 10.1002/JPER.17-0550. [Epub ahead of print]


Oral Infection with P. gingivalis Exacerbates Autoimmune Encephalomyelitis.

  • Polak D, Shmueli A, Brenner T, Shapira L.
  • J Periodontol. 2018 Jul 20. doi: 10.1002/JPER.17-0531. [Epub ahead of print]


Multiple Regulatory Levels of Growth Arrest-Specific 6 in Mucosal Immunity Against an Oral Pathogen.

  • Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Saba F, Salameh R, Eli-Berchoer L, Wilensky A, Burstyn-Cohen T, Hovav AH.
  • Front Immunol. 2018 Jun 18;9:1374. doi: 10.3389/fimmu.2018.01374. eCollection 2018.


Periodontal Health and Gingival Diseases and Conditions On an Intact and a Reduced Periodontium: Consensus Report of Workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

  • Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H.
  • J Periodontol. 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719.


Periodontal Health and Gingival Diseases and Conditions on an Intact and a Reduced Periodontium: Consensus Report of Workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

  • Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H.
  • J Clin Periodontol. 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940.


Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis.

  • Mizraji G, Heyman O, Van Dyke TE, Wilensky A.
  • Front Immunol. 2018 Apr 25;9:785. doi: 10.3389/fimmu.2018.00785. eCollection 2018.


Cell-Intrinsic Regulation of Murine Epidermal Langerhans Cells by Protein S.

  • Tabib Y, Jaber NS, Nassar M, Capucha T, Mizraji G, Nir T, Koren N, Aizenbud I, Maimon A, Eli-Berchoer L, Wilensky A, Burstyn-Cohen T, Hovav AH.
  • Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5736-E5745. doi: 10.1073/pnas.1800303115. Epub 2018 Jun 5.


Microbial Accumulation on Different Suture Materials Following Oral Surgery: A Randomized Controlled Study.

  • Asher R, Chacartchi T, Tandlich M, Shapira L, Polak D.
  • Clin Oral Investig. 2018 May 2. doi: 10.1007/s00784-018-2476-0. [Epub ahead of print]


Periodontal Education and Assessment in the Undergraduate Dental Curriculum-A Questionnaire-Based Survey in European Countries.

  • Gürsoy M, Wilensky A, Claffey N, Herrera D, Preshaw PM, Sanz M, Schlagenhauf U, Trombelli L, Demirel K.
  • Eur J Dent Educ. 2018 Aug;22(3):e488-e499. doi: 10.1111/eje.12330. Epub 2018 Feb 20.


An Update On the Evidence For Pathogenic Mechanisms That May Link Periodontitis and Diabetes.

  • Polak D, Shapira L.
  • J Clin Periodontol. 2018 Feb;45(2):150-166. doi: 10.1111/jcpe.12803. Epub 2017 Dec 26.


Scientific Evidence on the Links between Periodontal Diseases and Diabetes: Consensus Report and Guidelines of the Joint Workshop on Periodontal Diseases and Diabetes by the International Diabetes Federation and the European Federation of Periodontology.

  • Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D.
  • J Clin Periodontol. 2018 Feb;45(2):138-149. doi: 10.1111/jcpe.12808. Epub 2017 Dec 26.


Association of Dental and Maxillary Sinus Pathologies With Ear, Nose, and Throat Symptoms.

  • Horwitz Berkun R, Polak D, Shapira L, Eliashar R.
  • Oral Dis. 2018 May;24(4):650-656. doi: 10.1111/odi.12805. Epub 2017 Nov 24.


Dental Treatment in the Era of New Anti-Thrombotic Agents.

  • Sahar-Helft S, Chackartchi T, Polak D, Findler M.
  • Int Dent J. 2018 Jun;68(3):131-137. doi: 10.1111/idj.12322. Epub 2017 Sep 17. Review.


Is Aggregatibacter actinomycetemcomitans the Missing Link between Periodontitis and Rheumatoid Arthritis?

  • Polak D.
  • Oral Dis. 2018 Oct;24(7):1148-1149. doi: 10.1111/odi.12701. Epub 2017 Aug 2. No abstract 

year 2017

Oral Fibroblasts Modulate the Macrophage Response To Bacterial Challenge.

  • Tzach-Nahman R, Nashef R, Fleissig O, Palmon A, Shapira L, Wilensky A, Nussbaum G.
  • Sci Rep. 2017 Sep 14;7(1):11516. doi: 10.1038/s41598-017-11771-3.


Hard and Soft Tissue Integration of Immediate and Delayed Implants with a Modified Coronal Macrodesign: Histological, Micro-CT and Volumetric Soft Tissue Changes From a Pre-Clinical In Vivo Study.

  • Sanz-Martin I, Vignoletti F, Nuñez J, Permuy M, Muñoz F, Sanz-Esporrín J, Fierravanti L, Shapira L, Sanz M.
  • J Clin Periodontol. 2017 Aug;44(8):842-853. doi: 10.1111/jcpe.12747. Epub 2017 Jul 26.


Oral Infection with Porphyromonas gingivalis Induces Peri-Implantitis in a Murine Model: Evaluation of Bone Loss and the Local Inflammatory Response.

  • Tzach-Nahman R, Mizraji G, Shapira L, Nussbaum G, Wilensky A.
  • J Clin Periodontol. 2017 Jul;44(7):739-748. doi: 10.1111/jcpe.12735. Epub 2017 Jun 23.


Role of Microbial Biofilms in the Maintenance of Oral Health and in the Development of Dental Caries and Periodontal Diseases. Consensus Report of Group 1 of the Joint EFP/ORCA Workshop on the Boundaries between Caries and Periodontal Disease.

  • Sanz M, Beighton D, Curtis MA, Cury JA, Dige I, Dommisch H, Ellwood R, Giacaman RA, Herrera D, Herzberg MC, Könönen E, Marsh PD, Meyle J, Mira A, Molina A, Mombelli A, Quirynen M, Reynolds EC, Shapira L, Zaura E.
  • J Clin Periodontol. 2017 Mar;44 Suppl 18:S5-S11. doi: 10.1111/jcpe.12682.


Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation.

  • Mizraji G, Nassar M, Segev H, Sharawi H, Eli-Berchoer L, Capucha T, Nir T, Tabib Y, Maimon A, Dishon S, Shapira L, Nussbaum G, Wilensky A, Hovav AH.
  • Cell Rep. 2017 Jan 10;18(2):419-431. doi: 10.1016/j.celrep.2016.12.047.


Analysis of Leukocytes in Oral Mucosal Tissues.

  • Wilensky A, Mizraji G, Tabib Y, Sharawi H, Hovav AH.
  • Methods Mol Biol. 2017;1559:267-278. doi: 10.1007/978-1-4939-6786-5_18.


GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa.

  • Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Pevsner-Fischer M, Zilberman-Schapira G, Heyman O, Nussbaum G, Bercovier H, Wilensky A, Elinav E, Burstyn-Cohen T, Hovav AH.
  • Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E337-E346. doi: 10.1073/pnas.1614926114. Epub 2017 Jan 3.


Porphyromonas gingivalis Capsule-Mediated Coaggregation as a Virulence Factor in Mixed Infection with Fusobacterium nucleatum.

  • Polak D, Ferdman O, Houri-Haddad Y.
  • J Periodontol. 2017 May;88(5):502-510. doi: 10.1902/jop.2016.160397. Epub 2016 Nov 25.


Vaccination with Recombinant RgpA Peptide Protects Against Porphyromonas gingivalis-Induced Bone Loss.

  • Wilensky A, Potempa J, Houri-Haddad Y, Shapira L.
  • J Periodontal Res. 2017 Apr;52(2):285-291. doi: 10.1111/jre.12393. Epub 2016 Jun 10.


Epidemiology of Gingivitis in Schoolchildren in Bucharest, Romania: A Cross-Sectional Study.

  • Funieru C, Klinger A, Băicuș C, Funieru E, Dumitriu HT, Dumitriu A.
  • J Periodontal Res. 2017 Apr;52(2):225-232. doi: 10.1111/jre.12385. Epub 2016 Apr 19.

year 2016

CX3CR1hi Monocyte/Macrophages Support Bacterial Survival and Experimental Infection-Driven Bone Resorption.

  • Steinmetz O, Hoch S, Avniel-Polak S, Gavish K, Eli-Berchoer L, Wilensky A, Nussbaum G.
  • J Infect Dis. 2016 May 1;213(9):1505-15. doi: 10.1093/infdis/jiv763. Epub 2015 Dec 23.


Lethal Bacterial Trap: Cationic Surface for Endodontic Sealing.

  • Kesler Shvero D, Zaltsman N, Weiss EI, Polak D, Hazan R, Beyth N.
  • J Biomed Mater Res A. 2016 Feb;104(2):427-34. doi: 10.1002/jbm.a.35576. Epub 2015 Oct 20.

year 2015

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes.

  • Capucha T, Mizraji G, Segev H, Blecher-Gonen R, Winter D, Khalaileh A, Tabib Y, Attal T, Nassar M, Zelentsova K, Kisos H, Zenke M, Seré K, Hieronymus T, Burstyn-Cohen T, Amit I, Wilensky A, Hovav AH.
  • Immunity. 2015 Aug 18;43(2):369-81. doi: 10.1016/j.immuni.2015.06.017. Epub 2015 Jul 28.


Are Anti-Inflammatory Agents Effective in Treating Gingivitis As Solo or Adjunct Therapies? A Systematic Review.

  • Polak D, Martin C, Sanz-Sánchez I, Beyth N, Shapira L.
  • J Clin Periodontol. 2015 Apr;42 Suppl 16:S139-51. doi: 10.1111/jcpe.12340. Review.


Porphyromonas gingivalis gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection.

  • Wilensky A, Tzach-Nahman R, Potempa J, Shapira L, Nussbaum G.
  • J Innate Immun. 2015;7(2):127-135. doi: 10.1159/000365970. Epub 2014 Sep 16.